产品货号：
GS4487
中文名称：
重组小鼠IL-33
英文名称：
Recombinant Murine Interleukin-33
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.5kDaprotein containing 158 amino acid residues.
储存条件：冷冻（-20℃）
概述
IL-33 is a number of IL-1 superfamily,secreted by high endothelial venules at high levels,which is found in tonsils,peyer patches and mesenteric lymph nodes,but not in placenta.It elicits its biological effects by interacting with IL1RL1/ST2 and its stimulation recruits MYD88,IRAK1,IRAK4,and TRAF6,followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,MAPK14,and MAPK8.IL-33 induces production of TH2 cell related cytokines,including IL-4,IL-5 and IL-13,and exerts multiple inflammation related bioactivities.Mature IL-33 share approximately 55%and 90%a.a.sequence identity with human and rat IL-33 respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IL-33，IL-33, Murine，Recombinant Murine Interleukin-33
储存条件：冷冻（-20℃）
概述
IL-33 is a number of IL-1 superfamily,secreted by high endothelial venules at high levels,which is found in tonsils,peyer patches and mesenteric lymph nodes,but not in placenta.It elicits its biological effects by interacting with IL1RL1/ST2 and its stimulation recruits MYD88,IRAK1,IRAK4,and TRAF6,followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,MAPK14,and MAPK8.IL-33 induces production of TH2 cell related cytokines,including IL-4,IL-5 and IL-13,and exerts multiple inflammation related bioactivities.Mature IL-33 share approximately 55%and 90%a.a.sequence identity with human and rat IL-33 respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞98%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5ng/ml,corresponding to a specific activity of>2.0×106 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in PBS,and 1mMEDTA. |
| 内毒素 | Less than 1 EU/μg of rMuIL-33 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI |
相关搜索：重组小鼠IL-33，IL-33, Murine，Recombinant Murine Interleukin-33